Last update
9/29/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
500 mg
119%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Improved sleep quality
12 people found this helpful
This magnesium is fantastic, and I wouldn't choose anything else! It effectively calms my nervous system and enhances my sleep. I combine it with vitamin B6. The tablets are large yet easy to swallow. This magnesium is the best I have found, and I plan to reorder once I finish. Thank you to the manufacturer for affordable quality.
Read More
7.5
Leg cramps resolved
After discovering I had low magnesium levels and experiencing muscle cramps, I decided to try this product at my gynecologist's suggestion. I didn't regret it one bit. There was no discomfort, and I instantly felt a soothing sense of calm. Apparently, it works well for me as my leg cramps have completely stopped!
Read More
9
Improved mood
11 people found this helpful
Excellent Magnesium! I am currently expecting a baby and dealing with immense stress and sleep issues. My doctor suggested Magnesium for my body. Amazingly, I noticed results after the first dose! I took a pill in the evening, and the next day, even my husband didn’t irritate me! I ordered three jars: one for myself, one for my mother, and one for my aunt. I plan to complete my course before it becomes too late during the pregnancy.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved sleep quality
12 people found this helpful
This magnesium is fantastic, and I wouldn't choose anything else! It effectively calms my nervous system and enhances my sleep. I combine it with vitamin B6. The tablets are large yet easy to swallow. This magnesium is the best I have found, and I plan to reorder once I finish. Thank you to the manufacturer for affordable quality.
Read More
7.5
Leg cramps resolved
After discovering I had low magnesium levels and experiencing muscle cramps, I decided to try this product at my gynecologist's suggestion. I didn't regret it one bit. There was no discomfort, and I instantly felt a soothing sense of calm. Apparently, it works well for me as my leg cramps have completely stopped!
Read More
9
Improved mood
11 people found this helpful
Excellent Magnesium! I am currently expecting a baby and dealing with immense stress and sleep issues. My doctor suggested Magnesium for my body. Amazingly, I noticed results after the first dose! I took a pill in the evening, and the next day, even my husband didn’t irritate me! I ordered three jars: one for myself, one for my mother, and one for my aunt. I plan to complete my course before it becomes too late during the pregnancy.
Read More
9
Consistent sleep improvement
1 people found this helpful
I was initially sceptical about magnesium, but after taking it for two weeks, I found it genuinely effective. I previously suffered from intermittent sleep, waking up after four hours. Now, after a week on this supplement, I sleep through the night, achieving five uninterrupted hours initially, and now I rest entirely. I am thrilled and plan on reordering shortly!
Read More
7.5
Mood enhancement observed
1 people found this helpful
I purchased this product during a depressive episode, and after a month, my mood improved significantly. I even ordered it for my mother and mother-in-law, who are also very pleased with the results. I'm sure I'll continue to buy it based on its effectiveness.
Read More
Frequently Asked Questions
9
Improved mood
11 people found this helpful
Excellent Magnesium! I am currently expecting a baby and dealing with immense stress and sleep issues. My doctor suggested Magnesium for my body. Amazingly, I noticed results after the first dose! I took a pill in the evening, and the next day, even my husband didn’t irritate me! I ordered three jars: one for myself, one for my mother, and one for my aunt. I plan to complete my course before it becomes too late during the pregnancy.
9
Consistent sleep improvement
1 people found this helpful
I was initially sceptical about magnesium, but after taking it for two weeks, I found it genuinely effective. I previously suffered from intermittent sleep, waking up after four hours. Now, after a week on this supplement, I sleep through the night, achieving five uninterrupted hours initially, and now I rest entirely. I am thrilled and plan on reordering shortly!
2
Poor absorption noted
1 people found this helpful
Unfortunately, I found that this form of magnesium didn't meet my expectations. It poorly absorbed compared to chelated forms and even caused my stomach discomfort. I switched back to my previous magnesium brand since it worked better for me. While some may find it beneficial, I personally did not.
7.5
Leg cramps resolved
After discovering I had low magnesium levels and experiencing muscle cramps, I decided to try this product at my gynecologist's suggestion. I didn't regret it one bit. There was no discomfort, and I instantly felt a soothing sense of calm. Apparently, it works well for me as my leg cramps have completely stopped!
7.5
Mood enhancement observed
1 people found this helpful
I purchased this product during a depressive episode, and after a month, my mood improved significantly. I even ordered it for my mother and mother-in-law, who are also very pleased with the results. I'm sure I'll continue to buy it based on its effectiveness.
9
Improved sleep quality
12 people found this helpful
This magnesium is fantastic, and I wouldn't choose anything else! It effectively calms my nervous system and enhances my sleep. I combine it with vitamin B6. The tablets are large yet easy to swallow. This magnesium is the best I have found, and I plan to reorder once I finish. Thank you to the manufacturer for affordable quality.
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
We explored the relationship between dietary magnesium intake and all-cause mortality in patients with rheumatoid arthritis (RA) using data from the NHANES database.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. 10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. 10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. 10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. 10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. 10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. 10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
